Table 3.
Factors associated with having a low RDI (RDI < 100 %) among DLBCL patients treated with CHOP21/RCHVP (n = 294)
| Model 2a | Model 2b | Model 2c | Model 2d | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| beta [95 % CI] p-value | beta [95 % CI] p-value | beta [95 % CI] p-value | beta [95 % CI] p-value | ||||||||||||||
| Age | 56 – 65 y | 1 | 1 | 1 | |||||||||||||
| 66 to 75y | 0.4 | [0.2; | 0.8] | 0.008 | 0.4 | [0.2; | 0.8] | 0.014 | 0.4 | [0.2; | 0.8] | 0.010 | |||||
| At least 76y | 0.6 | [0.2; | 1.4] | 0.206 | 0.6 | [0.3; | 1.5] | 0.265 | 0.6 | [0.2; | 1.4] | 0.246 | |||||
| Gender | Men | 1 | 1 | 1 | |||||||||||||
| Women | 1.4 | [0.8; | 2.6] | 0.242 | 1.4 | [0.8; | 2.6] | 0.233 | 1.4 | [0.8; | 2.6] | 0.251 | |||||
| Comorbidity | None | 1 | 1 | 1 | |||||||||||||
| At least 1 | 1.2 | [0.6; | 2.2] | 0.572 | 1.2 | [0.6; | 2.2] | 0.653 | 1.2 | [0.6; | 2.3] | 0.583 | |||||
| Performance status | Normal | 1 | 1 | 1 | |||||||||||||
| Degraded | 1.5 | [0.7; | 3.1] | 0.310 | 1.4 | [0.7; | 3.1] | 0.354 | 1.3 | [0.6; | 2.9] | 0.480 | |||||
| Stage | I/II | 1 | 1 | 1 | |||||||||||||
| III/IV | 1.4 | [0.8; | 2.7] | 0.282 | 1.5 | [0.8; | 2.8] | 0.211 | 1.5 | [0.8; | 2.8] | 0.235 | |||||
| B symptoms | Absence | 1 | 1 | 1 | |||||||||||||
| Presence | 1.4 | [0.6; | 3.1] | 0.472 | 1.4 | [0.6; | 3.2] | 0.441 | 1.2 | [0.5; | 2.9] | 0.626 | |||||
| Lactate dehydrogenase | Normal | 1 | 1 | 1 | |||||||||||||
| Elevated | 1.2 | [0.7; | 2.3] | 0.491 | 1.1 | [0.6; | 2.1] | 0.679 | 1.1 | [0.6; | 2.0] | 0.814 | |||||
| Social deprivation index | Highly fav. | 1 | 1 | ||||||||||||||
| Favored | 0.6 | [0.2; | 1.8] | 0.403 | 0.7 | [0.2; | 2.0] | 0.508 | |||||||||
| Intermediate | 0.7 | [0.3; | 1.7] | 0.387 | 0.7 | [0.3; | 1.8] | 0.444 | |||||||||
| Deprived | 1.1 | [0.5; | 2.7] | 0.842 | 1.1 | [0.5; | 2.8] | 0.815 | |||||||||
| Highly dep. | 1.0 | [0.4; | 2.6] | 0.993 | 1.0 | [0.4; | 2.6] | 0.935 | |||||||||
| Distance to the care center (km) | Up to 13 km | 1 | 1 | ||||||||||||||
| 14 – 40 km | 1.0 | [0.5; | 2.1] | 0.995 | 1.2 | [0.6; | 2.5] | 0.687 | |||||||||
| At least 41 km | 1.6 | [0.7; | 3.3] | 0.266 | 1.5 | [0.7; | 3.3] | 0.323 | |||||||||
| Hospitalization for toxicity | None | 1 | |||||||||||||||
| At least 1 day | 2.8 | [1.4; | 5.7] | 0.006 | |||||||||||||
| Type of care center | UH | 1 | 1 | 1 | 1 | ||||||||||||
| CH | 2.3 | [1.2; | 4.6] | 0.019 | 2.2 | [1.0; | 4.8] | 0.039 | 2.6 | [1.2; | 5.6] | 0.020 | 1.9 | [0.8; | 4.4] | 0.120 | |
| PH | 2.4 | [1.2; | 4.6] | 0.010 | 2.8 | [1.4; | 5.6] | 0.005 | 3.3 | [1.6; | 7.1] | 0.002 | 3.3 | [1.5; | 7.1] | 0.002 | |
All the models were adjusted for centre effect using a random intercept which is not presented as its variance in all the models was smaller than 10−8, this may be interpreted as a random intercept variance not statistically different from zero. Global p-values in model 2a type of care center: p < 0.016; in model 2b age: p = 0.029, type of care center: p = 0.013; in model 2c age: p = 0.050, social deprivation index: p = 0.709, distance to the care center: p = 0.456, type of care center: p = 0.005; in model 2d age: p = 0.037, social deprivation index: p = 0.805, distance to the care center: p = 0.612, type of care center: p = 0.009