Table 3.

Multivariable logistic regression analyses assessing the association between predictive variables and the response to POC at cystectomy

Multivariable model A	CR (n = 35) vs. NR (n = 77)
Step 1	OR (95% CI)	P-value	AUC (95% CI)	Optimism-corrected AUC
dNLR, dichotomized	2.08 (0.69–6.33)	0.20	0.78 (0.68–0.88)
Hemoglobin at baseline	0.91 (0.54–1.56)	0.74
Lymphadenopathy	5.21 (1.69–16.11)	<0.01
Hydronephrosis	0.97 (0.29–3.24)	0.96
Clinical T stage (T1 reference)	–	–
T2	7.17 (0.47–109.83)	0.16
T3	9.39 (0.63–139.95)	0.10
T4	23.24 (1.34–404.12)	0.03
POC regimen	0.75 (0.23–2.40)	0.63
Final step
Lymphadenopathy	5.49 (1.85–16.33)	<0.01	0.75 (0.64–0.86)	0.72
Clinical T stage (T1 reference)	–	–
T2	7.97 (0.56–114.00)	0.13
T3	11.11 (0.82–150.25)	0.07
T4	30.30 (1.94–473.87)	0.02
Multivariable model B	CR (n = 35) + PR (n = 11) vs. NR (n = 77)
Step 1	OR (95% CI)	P-value	AUC (95% CI)	Optimism-corrected AUC
dNLR, dichotomized	1.17 (0.43–3.17)	0.76	0.75 (0.65–0.85)
Hemoglobin at baseline	0.81 (0.49–1.34)	0.41
Lymphadenopathy	4.09 (1.53–10.93)	<0.01
Extravesical extension	2.21 (0.71–6.87)	0.17
Clinical T stage (T1 reference)	–	–
T2	5.93 (0.41–86.07)	0.19
T3	4.12 (0.30–56.27)	0.29
T4	6.08 (0.39–95.83)	0.20
POC regimen	0.65 (0.23–1.88)	0.43
Final step
Lymphadenopathy	3.81 (1.52–9.57)	<0.01	0.71 (0.60–0.82)	0.68
Extravesical extension	2.89 (1.14–7.31)	0.03

CR, complete response; NR, non-response; OR, odds ratio; AUC, area under the Receiver Operating Characteristic curve; dNLR, derived neutrophil-to-lymphocyte ratio.