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Effect of LA1011 treatment on Morris water maze performance. The fitted survival curves using the Cox Proportional Hazard model represents the probability that animals find the platform during a trial, capped at 90 s. The effect of day has been modeled in. We compared wt+saline versus wt+LA1011 (p = 0.047), wt+saline versus tg+saline (p = 0.036), and tg+saline versus tg+LA1011 (p = 0.001) treatment groups using log-rank tests (n = 8/group).
