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. 2016 Aug 2;6:30719. doi: 10.1038/srep30719

Figure 3. Pharmacological evaluations of mERG components and RGC spike responses in C57BL/6 mouse retinas.

Figure 3

(a) Representative mERG patterns with and without exposure to 20 μM L-AP4 (average of 3 responses). (b) Effects of L-AP4 on the a-wave amplitudes (mean ± SD of 192 channels of 3 retinas). *P < 0.001, Kruskal-Wallis test. (c) Effects of L-AP4 on the implicit time of the a-wave (mean ± SD of 192 channels of 3 retinas). *P < 0.001, Kruskal-Wallis test. (d) Representative mERGs with or without exposure to L-AP4 and 6 mM PDA (averaged from the responses to 3 serial 0.45 log cd/m2 stimuli). Note that time calibration is modified in this figure for a better visualization of the changes in the a-wave. (e) Effects of L-AP4 only and L-AP4 with PDA on the a-wave amplitudes (mean ± SD of 192 channels in 3 retinas). *P < 0.001, Kruskal-Wallis test. (f) Representative RGC responses with and without L-AP4. (g) Corresponding peristimulus time histograms (PSTHs) of addition of spike numbers from all the 64 channels. All of the recorded responses were analyzed using spike sorting, and the summation of the firings of all of the RGCs are shown as PSTHs. (h) Representative RGC responses with L-AP4, and L-AP4 with PDA.