Table 2. CpG site-specific methylation for significant disorder and adversity types in comparison with No Adversity/No Disorder group.
CpG site | Depressive Disorder (n=115) | Anxiety Disorder (n=40) | Past Substance Disorder (n=75) | Emotional Abuse (n=83) | Emotional Neglect (n=88) | Physical Neglect (n=55) | Parental Desertion (n=51) |
---|---|---|---|---|---|---|---|
Mean | 7.54** | 5.89* | 3.89* | 6.45* | 6.63* | 7.19** | 6.99** |
1 | ns | ns | ns | ns | ns | ns | ns |
2 | ns | ns | ns | ns | ns | ns | ns |
3 | ns | ns | ns | ns | ns | ns | ns |
4 | ns | ns | ns | ns | ns | ns | ns |
5 | ns | ns | ns | ns | ns | ns | ns |
6 | 14.56*** | 11.75*** | 7.40** | 8.02** | 11.60*** | 8.65** | 12.67*** |
7 | 3.44t | 5.08* | ns | 3.59t | 3.38t | 4.37* | ns |
8 | ns | ns | ns | 3.49t | ns | 3.15t | 3.34t |
9 | 19.56*** | 14.05*** | 8.25** | 11.02*** | 12.35*** | 12.71*** | 8.77** |
10 | 6.09* | 5.28* | ns | 6.06* | 5.33* | 9.47** | 5.18* |
11 | 6.07* | 5.59* | 3.15t | 5.76* | 4.84* | 6.96** | 5.79* |
12 | 21.02*** | 13.01*** | 8.64** | 14.03*** | 15.94*** | 17.66*** | 11.24*** |
13 | 12.48*** | 12.47*** | 7.03** | 7.76** | 8.07** | 10.33** | 5.68* |
Abbreviation: ns, not significant.
Note: All table values represent the F statistic. tP<0.10, *P<0.05, **P<0.01, ***P<0.001.