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Pie chart depicting the functional classification of differentially regulated hippocampal proteins during learning and memory between NonTg and 3 × Tg-AD mice. The iTRAQ-identified changes in the hippocampal proteome were characterized using gene ontology (GO) analysis. Subcellular and functional categories were based on the annotations of GO using the PANTHER Classification System for the categories of Biological process, Molecular function, Protein class and Cellular component.
