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. 2016 Aug;148(2):133–145. doi: 10.1085/jgp.201611614

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© 2016 Gosselin-Badaroudine et al.

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Figure 7. — Ionic selectivity of the mutated AmCa_V4/E1797K channel (DEKA selectivity filter). (A) Representative current traces recorded with oocytes expressing AmCa_V4/E1797K in Ringer’s and modified Ringer’s solutions. (B) Mean change in the normalized peak current after removal of a permeable ion. For each oocyte, the peak current in a given solution was divided by the peak current measured in the Ringer’s solution and subtracted by 100% (n = 5). Data are expressed as means ± SEM. Statistical differences with peak currents measured in Ringer’s solution are identified with asterisks (**, P < 0.01; ***, P < 0.001). Outward currents were measured in the absence of sodium, whereas inward currents were measured in Ringer’s solution.