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. 2016 Aug 2;12:159. doi: 10.1186/s12917-016-0774-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Synergistic combinations of TE and RE. Percent proliferating cells of control are represented as mean ± SEM and were determined by MTT assay on C2 (a), CMT-12 (b), and D17 (c) cell lines. TE and RE were used individually (dashed lines) or in combination at equal concentrations (solid line) at doses ranging from 0.8 to 25 μg mL⁻¹. Lowest dose that induced a significant (p < 0.05) decrease in percent proliferation compared to DMSO control indicated by + (TE alone), # (RE alone), and ^ (dual extract combination)