Table 4.

Combinatorial effects of TE/RE and chemotherapy on tumor cell proliferation

Combination Index (CI) values on C2 (A-C), CMT-12 (D-F), and D17 (G-I) cell lines treated with TE and RE in combination at doses of 0.8, 1.7, 3.1, and 6.3 μg mL⁻¹ in the presence of chemotherapeutic agents. Toceranib phosphate used for C2 cell line at (A) IC₂₅ dose of 6.3 nM, (B) IC₅₀ dose of 12.5 nM, and (C) IC₇₅ dose of 12.5 nM; doxorubicin hydrochloride was used for the CMT-12 cell line at (D) IC₂₅ dose of 0.1 μM, (E) IC₅₀ dose of 0.3 μM, and (F) IC₇₅ dose of 1 μM; doxorubicin hydrochloride was used for the D17 cell line at (G) IC₂₅ dose of 0.3 μM, (H) IC₅₀ dose of 0.5 μM, and (I) IC₇₅ dose of 2 μM. CI values ≤ 0.9 indicate synergism (bold values), a CI value >0.9 and <1.1 indicates an additive effect, and CI values ≥1.1 indicate antagonism (italicized value)