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. Author manuscript; available in PMC: 2016 Aug 2.

Published in final edited form as: Mol Pharm. 2016 Feb 1;13(3):839–851. doi: 10.1021/acs.molpharmaceut.5b00763

Table 2. Estimation of CQ Maximum Unbound Concentration at the Inlet to the Liver (I_u,in,max).

variable
dose of CQ (mg)^a	191⁴⁸	300³⁹	600⁴⁹
C_max (μM)	0.72–12.18⁴⁸	0.24³⁹	1.2⁴⁹
I_u,in,maxb^b (μM)	18.3–23.4	28.2	56.8

^a

CQ doses were converted to CQ base.

^b

Estimated on the basis of eq 1.