Table 2.
Location and peak significance of grey matter volume loss using VBM-DARTEL
| Voxel level (P FWE) | Extent (k) | T, Z scores | MNI coordinates (x, y, z) (mm) | Region | |
|---|---|---|---|---|---|
| Pro-DLB vs. control subjects | <0.001 | 2361 | 7.1, 6.0 | 11, 57, 18 | Right superior frontal |
| 7.1, 6.0 | 9, 50, 13 | Right paracingulate | |||
| <0.001 | 461 | 6.8, 5.8 | −38, 11, 13 | Left insula | |
| 0.001 | 1321 | 6.4, 5.5 | −29, 24, −6 | Left insula | |
| 0.001 | 340 | 6.1, 5.3 | −8, −63, 45 | Left precuneus | |
| 0.002 | 53 | 5.9, 5.2 | 14, −43, 43 | Right precuneus | |
| 0.002 | 359 | 5.9, 5.2 | 30, 29, −3 | Right inferior frontal | |
| 0.006 | 137 | 5.6, 5.0 | 39, 5, 7 | Right insula | |
| 0.009 | 35 | 5.5, 4.9 | 5, 68, −3 | Right medial frontal | |
| 0.016 | 25 | 5.3, 4.8 | −14, 60, 7 | Left medial frontal | |
| 0.017 | 15 | 5.3, 4.8 | −29, 29, 40 | Left middle frontal | |
| 0.018 | 31 | 5.3, 4.7 | 26, 56, −11 | Right superior frontal | |
| 0.033 | 12 | 5.1, 4.6 | −14, 47, 0 | Left anterior cingulate | |
| Pro-AD vs. control subjects | <0.001 | 24,640 | 9.8, 7.4 | 12, 59, −15 | Right medial frontal |
| 8.6, 6.8 | 50, 47, −3 | Right inferior frontal | |||
| 8.0, 6.5 | −30, −19, −18 | Left hippocampus | |||
| 7.4, 6.2 | 42, 54, −14 | Right middle frontal | |||
| 7.3, 6.1 | −44, 26, −5 | Left inferior frontal | |||
| 7.3, 6.1 | −12, 62, −3 | Left medial frontal | |||
| 7.3, 6.1 | −9, 69, −-9 | Left superior frontal | |||
| <0.001 | 1144 | 6.7, 5.7 | 35, 21, −42 | Right temporal pole | |
| 6.1, 5.3 | 39, 8, −33 | Right superior temporal | |||
| 0.001 | 1881 | 6.3, 5.5 | 12, −39, 42 | Right posterior cingulate | |
| 6.1, 5.3 | −8, −39, 40 | Left posterior cingulate | |||
| 0.002 | 176 | 6.0, 5.2 | 33, −81, −53 | Right posterior cerebellum | |
| 0.003 | 67 | 5.9, 5.2 | 11, −9, 39 | Right mid-cingulate | |
| 0.004 | 392 | 5.8, 5.1 | 15, 24, 61 | Right superior frontal | |
| 0.004 | 94 | 5.8, 5.1 | −47, −84, −9 | Left inferior occipital | |
| 0.004 | 145 | 5.8, 5.1 | −5, −48, −27 | Left anterior cerebellum | |
| 0.005 | 527 | 5.7, 5.0 | −33, −70, 39 | Left precuneus | |
| 0.007 | 178 | 5.6, 5.0 | −11, 15, 39 | Left mid-cingulate | |
| 0.008 | 113 | 5.5, 4.9 | 48, −76, 24 | Right middle temporal | |
| 0.011 | 12 | 5.4, 4.8 | 18, −72, 56 | Right superior parietal | |
| 0.011 | 137 | 5.4, 4.8 | 29, −12, −14 | Right hippocampus | |
| 0.012 | 42 | 5.4, 4.8 | −60, 2, −27 | Left middle temporal | |
| Pro-AD vs. pro-DLB | 0.006 | 79 | 5.6, 4.9 | 20, −42, 60 | Right superior parietal |
| Pro-DLB (hallucinators vs. non-hallucinators) | 0.002a | 82 | 3.1, 2.8 | −5, −84, 18 | Left cuneus BA17 |
Abbreviations: BA Brodmann area, FWE family-wise error, MNI Montreal Neurological Institute, pro-AD prodromal Alzheimer’s disease, pro-DLB prodromal dementia with Lewy bodies, VBM-DARTEL voxel-based morphometry with diffeomorphic anatomical registration through exponentiated lie algebra
Table depicts voxel-level significance (P FWE), spatial extent (k), T and Z scores, MNI coordinates and anatomical region
aUncorrected P value