Table 3.
Association between maternal alleles of AS3MT single nucleotide polymorphisms (SNPs) and urinary iAs metabolite levels and percentages.
| SNP rs (major allele>minor allele) | U-iAs (βc) | U-MMAs (β) | U-DMAs (β) | %iAs (β) | %MMAs (β) | %DMAs (β) |
|---|---|---|---|---|---|---|
| Model Ia | ||||||
| rs7085104 (A>G) | - | −0.453++ (−0.748, −0.157) | 0.768++ (0.214, 1.321) | - | −1.050++ (−1.645, −0.454) | 1.729++ (0.492, 2.966) |
| rs3740400 (T>G) | - | −0.452++ (−0.156, −0.747) | 0.731++ (1.286, 0.176) | - | −1.028++ (−0.431, −1.625) | 1.613+ (2.854, 0.372) |
| rs3740393 (G>C) | - | −0.422++ (−0.109, −0.736) | 0.669+ (1.257, 0.08) | - | −1.182++ (−0.555, −1.81) | 1.705+ (3.017, 0.394) |
| rs3740390 (C>T) | - | −0.494++ (−0.833, −0.154) | 0.703+ (0.061, 1.345) | - | −1.253++ (−1.94, −0.565) | 1.833+ (0.396, 3.269) |
| rs11191439 (T>C) d | - | - | - | - | - | - |
| rs10748835 (G>A) | - | −0.324+ (−0.637, −0.012) | - | - | −0.815+ (−1.446, −0.183) | - |
| rs1046778 (T>C) | - | −0.40++ (−0.707, −0.098) | 0.581+ (0.008, 1.153) | - | −1.012++ (−1.625, −0.399) | 1.510+ (0.235, 2.785) |
| Model II: Malesb | ||||||
| rs7085104 (A>G) | −0.390++ (−0.666, −0.115) | −0.356+ (−0.661, −0.052) | 0.731++ (0.236, 1.226) | −0.809+ (−1.522, − 0.096) | −1.091++ (−1.751, −0.432) | 1.814++ (0.711, 2.918) |
| rs3740400(T>G) | −0.313+ (−0.035,− 0.59) | −0.370+ (−0.069, −0.671) | 0.665++ (1.160, 0.170) | - | −1.155++ (−0.506, −1.805) | 1.658++ (2.763, 0.552) |
| rs3740393 (G>C) | −0.410++ (−0.109, −0.71) | −0.464++ (−0.138, −0.791) | 0.858++ (1.393, 0.324) | −1.005++ (0.235, 1.776) | −1.323++ (−0.613, −2.033) | 2.201++ (3.390, 1.011) |
| rs3740390 (C>T) | −0.386+ (−0.712, −0.06) | −0.519++ (−0.869, −0.169) | 0.899++ (0.324, 1.475) | −0.885+ (−1.721, − 0.049) | −1.401++ (−2.163, −0.639) | 2.366++ (1.095, 3.638) |
| rs11191439 (T>C) d | - | 1.064++ (0.480, 1.648) | −1.585++ (−2.562, −0.607) | - | 1.362+ (0.002, 2.721) | - |
| rs10748835 (G>A) | - | - | - | - | −0.829+ (−1.542, −0.117) | 1.364+ (0.171, 2.557) |
| rs1046778 (T>C) | - | −0.425++ (−0.727, −0.123) | 0.675++ (0.174, 1.175) | - | −1.103++ (−1.765, −0.441) | 1.807++ (0.698, 2.917) |
| Model II: Femalesb | ||||||
| rs7085104 (A>G) | - | - | - | - | - | - |
| rs3740400(T>G) | - | - | - | - | - | - |
| rs3740393 (G>C) | - | - | - | - | - | - |
| rs3740390 (C>T) | - | - | - | - | - | - |
| rs11191439 (T>C) d | - | - | - | - | - | - |
| rs10748835 (G>A) | - | - | - | - | - | - |
| rs1046778 (T>C) | - | - | - | - | - | - |
p<0.05
p<0.01 (adjusted p-value).
Model I included maternal genotype as a primary predictor, controlling for the following covariates: U-tAs, maternal age, smoking status, drinking status, education level and fetal sex.
Model II included maternal genotype as a primary predictor, controlling for the following covariates: U-tAs, maternal age, smoking status, drinking status, and education level, stratified by fetal sex.
Beta (β) coefficients represent the estimated change in iAs metabolite levels or percentages resulting from the addition of one copy of the minor allele.
rs11191439 is a non-synonymous SNP in exon nine known to alter the amino acid sequence of AS3MT (Met287Thr).