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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Nat Immunol. 2016 Apr 4;17(5):538–544. doi: 10.1038/ni.3417

Figure 2.

Figure 2

Chronic HDM induces similar allergy in the lungs of wild-type and AMCase-deficient mice. (a) Histopathology scoring and representative sections stained with H&E (scale bar, 200 µm) from wild-type or AMCase-deficient (AMCase-KO) mice sensitized and challenged intranasally with PBS (n = 3 mice per genotype) or house dust mite (HDM) (n = 8 mice per genotype) for 45 d. (b) Quantification of eosinophils in the lung tissue of mice in a (PBS, n = 3; HDM, n = 9). (c) Intracellular cytokine analysis of lung tissue lymphocytes of mice in a (PBS, n = 3; HDM, n = 9). (d) Quantification of eosinophils in BALF of mice in a (PBS, n = 3; HDM, n = 9). (e) Intracellular cytokine analysis of BALF lymphocytes of mice in a (PBS, n = 3; HDM, n = 9). Data are pooled from two experiments with similar results. Error bars, s.e.m.; each data point represents a value for an individual mouse.