Table 2.
Variation in frequency of the common PNPLA3 polymorphism in different regions and among different ethnic groups
| Descent/ethnicity | Alleles C1 | Alleles G2 | Genotypes C|C | Genotypes C|G | Genotypes G|G |
Allele count |
Genotype count |
|||
| C allele | G allele | C|C | C|G | G|G | ||||||
| All (n = 2504) | 73.8% | 26.2% | 56.9% | 33.8% | 9.3% | 3695 | 1313 | 1424 | 847 | 233 |
| African (n = 661) | 88.2% | 11.8% | 78.8% | 18.8% | 2.4% | 1166 | 156 | 521 | 124 | 16 |
| Latin American (n = 347) | 51.6% | 48.4% | 27.7% | 47.8% | 24.5% | 358 | 336 | 96 | 166 | 85 |
| Asian (n = 504) | 65.0% | 35.0% | 44.0% | 41.9% | 14.1% | 655 | 353 | 222 | 211 | 71 |
| European (n = 503) | 77.4% | 22.6% | 60.2% | 34.4% | 5.4% | 779 | 227 | 303 | 173 | 27 |
| Southern Asian (n = 489) | 75.4% | 24.6% | 57.7% | 35.4% | 7.0% | 737 | 241 | 282 | 173 | 34 |
1
Allele C: Wild type;
2
Allele G: Variant rs738409, codes I148M protein.