Figure 5.
Overexpression of Mcl-1 in RPMI-8226 cells confers significantly less protection than over expression of Bcl-2 or Bcl-xL.RPMI-8226 cells overexpressing the anti-apoptotic proteins shown were treated with increasing doses of (A) carfilzomib (B) TG02 or (C) the combination for 24 hours. Cell death was determined via Annexin-V-FITC/PI flow cytometry. Data are presented as mean +/− SEM of at least 3 independent experiments. Statistical analysis for RPMI-8226 Mcl-1 over expressing cells only shown. *p > 0.05, **p > 0.01, ***p > 0.001.