Table 4.

Sites of first treatment failure

Location of failure	Placebo (n=1656)	Clodronate (n=1655)	p*
	n (%)	n (%)
Local	44 (3)	43 (3)	0.92
Regional	9(<1)	10 (<1)	0.80
Distant	113 (7)	90 (5)	0.11
Opposite breast	37 (2)	39 (2)	0.78
Second cancer, except opposite breast	79 (5)	70 (4)	0.50
Dead, no evidence of disease	30 (2)	34 (2)	0.58
Total alive, event free	1344 (81)	1369 (83)	–
Total events	312 (19)	286 (17)	0.27

^*Difference in cumulative incidence of failure sites between groups.