Figure 3.

DSS-induced colitis is greatly attenuated by deletion of Sgpp2. Acute colitis was induced in Sgpp1^−/− and Sgpp2^−/− mice and their corresponding WT littermates with 5% DSS in drinking water for 5 d followed by recovery for 5 d on normal drinking water. A–D) Changes in body weight (A, B) and blood stool scores (C, D) were determined; n = 10 mice per group. E, F) Circulating red blood cells (RBCs) (E) and white blood cells (WBCs) (F) were measured on d 10 in blood from Sgpp1^−/− and Sgpp2^−/− mice and their corresponding WT littermates that were treated without or with DSS. Data represent means ± sd. *P < 0.05 compared with water-treated mice. ^#P < 0.05 compared with WT + DSS group.