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Opposite effects on Sgpp1 and Sgpp2 deletion on DSS-induced proinflammatory cytokines. Acute colitis was induced with 5% DSS in WT, Sgpp1−/−, and Sgpp2−/− mice. A) Cytokine mRNA levels in the colons was determined by quantitative PCR. B) Cytokines secreted from ex vivo colon cultures were measured by ELISA. *P < 0.05 compared with water control group. #P < 0.05 compared with WT + DSS group.
