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. 2016 Jun 16;5:57–68. doi: 10.2147/ITT.S64795

Figure 3.

Figure 3

DC and naive T-cell interactions produce an adaptive immune response.

Notes: There are three signals required to initiate an adaptive immune response. The first is the presentation of antigen by the DCs to the T-cell via the MHC II–TCR interaction. Second, costimulatory molecules on the DCs such as CD40, CD80, and CD86 bind to their respective receptors on the T-cell to amplify the signal. Third, cytokines produced by the now activated T-cell skew the T-cell response toward a TH1, TH2, Treg, or TH17 response.

Abbreviations: DC, dendritic cell; IL-4, interleukin 4; IL-6, interleukin 6; IL-12, interleukin 12; MHCII, major histocompatibility complex class II; TCR, T-cell receptor; TGFβ, transforming growth factor beta; Treg, T regulatory cells; TH1, T helper 1; TH2, T helper 2; TH17, T helper 17.