Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 16;5:57–68. doi: 10.2147/ITT.S64795

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Burchell and Panegyres. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

The potential roles of CD4⁺ cells in prion disease.

Notes: CD4⁺ cells can be skewed into a T_H2 or T_reg phenotype in prion disease. T_H2 cells may aid in the differentiation of antibody-producing plasma cells from B-cells. T_H2 cells could increase the number and efficiency of secreted therapeutic antibodies by inducing an Ig class switch that could aid treatment of prion or neurological diseases. They may also be beneficial in advanced or familial prion disease by secreting proinflammatory cytokines that may attract macrophages to the brain in an attempt to clear prion deposits. T_reg cells can secrete the cytokines IL-10 or TGFβ to decrease inflammation when necessary.

Abbreviations: Ig, immunoglobulin; IgA, immunoglobulin A; IgG, immunoglobulin G; IL-4, interleukin 4; IL-10, interleukin 10; IL-13, interleukin 13; T_reg, T regulatory cells; T_H2, T helper 2; TGFβ, transforming growth factor beta.