Table 3.
Time course of threohydrobupropion β-d-glucuronide and erythrohydrobupropion β-d-glucuronide hydrolysis in patient urine by β-glucuronidase.
| (%) Glucuronide Remaininga (n = 3) |
|||
|---|---|---|---|
| Analyte | 4h | 8h | 24h |
| (1S,2S)-threohydrobupropion β-d-glucuronide | 10 ± 1 | 1 ± 0 | 0 ± 0 |
| (1S,2R)-erythrohydrobupropion β-d-glucuronide | 41 ± 1 | 19 ± 2 | 1 ± 0 |
| (1R,2R)-threohydrobupropion β-d-glucuronide | 83 ± 5 | 80 ± 3 | 73 ± 3 |
| (1R,2S)-erythrohydrobupropion β-d-glucuronide | 106 ± 3 | 88 ± 2 | 75 ± 5 |
a
Reported values are the percentage of the initial observed peak area ratio of glucuronides in patient urine (mean ± standard deviation, n = 3).