Table 1.
Substitution pattern and calculated log P values of the chalcones studied for their MDR reversal activity.
| ||||
|
| ||||
| Compound | Methoxylation pattern of ring A | R | log P | Referencea |
|
| ||||
| 1 | 3′,4′,5′- | –Cl | 4.0 | [8] |
| 2 | 3′,4′,5′- | –N(CH3)2 | 3.5 | [8] |
| 3 | 3′,4′,5′- | –OCH3 | 3.3 | [8] |
| 4 | 2′,3′,4′- | –Cl | 4.0 | [9, 10] |
| 5 | 2′,3′,4′- | –N(CH3)2 | 3.5 | [10] |
| 6 | 2′,3′,4′- | –OCH3 | 3.3 | [10] |
| 7 | 2′,4′,6′- | –Cl | 4.0 | [11] |
| 8 | 2′,4′,6′- | –N(CH3)2 | 3.5 | [11] |
| 9 | 2′,4′,6′- | –OCH3 | 3.3 | [11] |
| 10 | 3′,4′- | –Cl | 4.2 | — |
| 11 | 3′,4′- | –N(CH3)2 | 3.7 | [12] |
| 12 | 3′,4′- | –OCH3 | 3.4 | [13] |
| 13 | 2′,4′- | –Cl | 4.2 | [9] |
| 14 | 2′,4′- | –N(CH3)2 | 3.7 | [12, 14] |
| 15 | 2′,4′- | –OCH3 | 3.4 | [14] |
| 16 | 2′,5′- | –Cl | 4.2 | — |
| 17 | 2′,5′- | –N(CH3)2 | 3.7 | [12] |
| 18 | 2′,5′- | –OCH3 | 3.4 | [15] |
aChalcones reported by other sources.