Table 4.
Antiproliferative effects of chalcones 1–18 on L 5178 Y cells [μg/mL].
| Methoxylation pattern of ring A | ||||||
| p-Substituent in ring B | 3′,4′,5′-a | 2′,3′,4′- | 2′,4′,6′- | 2′,4′- | 3′,4′- | 2′,5′- |
|
| ||||||
| N(CH3)2 | <0.19 | 0.42 ± 0.14 | ≫50 | 43.18 ± 1.48 | >50 | 0.47 ± 0.01 |
| Cl | 0.14 | 2.16 ± 0.00 | 5.19 ± 0.14 | 4.98 ± 0.33 | 2.17 ± 0.31 | 4.95 ± 0.12 |
| OCH3 | <0.19 | 2.23 ± 0.28 | 22.75 ± 3.90 | 42.58 ± 18.03 | 5.06 ± 0.89 | 1.74 ± 0.07 |
aThe antiproliferative activity of chalcones having 3′,4′,5′-trimethoxylated pattern was determined previously [8].