Figure 5. Target genes of all 4 binding categories are regulated by endogenous and overexpressed PGC-1α in mouse muscle in vivo.

A–D, The expression of PGC-1α target genes with only ERRα DNA binding with (A) and without (B) adjacent SP1 motifs as well as of PGC-1α target genes with overlapping PGC-1α and ERRα peaks with (C) and without (D) SP1-binding sites was validated in skeletal MKO and mTg mice compared with the respective wild-type littermate controls.