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. 2016 Jan 13;24(8):1167–1174. doi: 10.1038/ejhg.2015.281

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Example of genomic profiles from DNAs extracted from FFPE and cellular and cfDNA from the urine from patient 23 with a stage G2 pT1 NMIBC. Comparison of profiles shows consistent aberrations identified in all three samples (red=loss, blue=gain and yellow=LOH). Aberrations from all three sources show homozygous loss at 9p21.3 including CDKN2A/B; listed in the TARGET database. Biallelic inactivation of CDKN2A/B may predict response to CDK4/6 inhibitors for this patient.