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. 2016 Jan 13;24(8):1167–1174. doi: 10.1038/ejhg.2015.281

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Copyright © 2016 Macmillan Publishers Limited

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Patient 7. DNAs extracted from urine provide improved quality genomic data and clearer characterisation of the tumour profile than DNA from FFPE tumour material, despite repeat slides being cut and extracted. Two TARGET aberrations (CCND1 amplification (may predict sensitivity to CDK4/6 inhibitors) and CCNE1 amplification (may predict sensitivity to CDK2 inhibitors)) were observed in both cfDNA and urinary cellular DNA however none of these aberrations were independently called in two separate DNAs from FFPE tumour material.