Table 1. Characteristics of patients and lesions considered in meta-analysis.
| Author, year | QUADAS2 bias risk | Applicability concerns | MRI Indications** | Patients | Age | Ref. standard*** | Lesions with FU only | FU months | Lesion size (mm) | Total cases | Malignancy prevalence |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lee, 1999 | P | No | 3 | 86 | 53 (30–80) | 1 | 54 | 19 (5–66) | 12.4 | 98 | 0.10 |
| Gökalp, 2006 | P | No | 2 | 43 | 49.7 (37–68) | 1 | 46 | >24 | 9.2 (3–21) | 56 | 0.02 |
| Moy, 2009 | P | No | 3 | 115 | 54 (32–72) | 1 | 100 | 34 (26–72) | 16 (10–29) | 115 | 0.05 |
| Pediconi, 2009 | P | No | 3 | 97 | 47.5 (16–77) | 1 | NA | >18 | NA | 97 | 0.56 |
| Benndorf, 2010 | P | No | 1, 2 | 113* | 54.4 ±11,8 | 1 | NA | >12 | NA | 113 | 0.12 |
| El-Barhoun, 2011 | P | No | 3 | 41* | NA | 1 | 8 | >6 | NA | 41 | 0.12 |
| Yau, 2011 | P, R | No | 3 | 204 | NA | 1 | 61° | 12 | NA | 204 | 0.07 |
| Dorrius, 2012 | P | No | 3 | 25 | 48.7 (32–69) | 2 | no FU | no FU | 10-80m 10-21b | 26 | 0.50 |
| Lobrano, 2012 | P | No | 3 | 66* | 55 (20–89) | 1 | 36°° | NA | NA | 126 | 0.08 |
| Olsen, 2012 | P | No | 3 | 51* | 52 (31–84) | 1 | 29 | 12 | NA | 51 | 0.04 |
| Bick, 2013 | P, R | No | 3 | 135 | 57.3 (50–70) | 1 | 52°°° | 24 | 12 ≤10 16 >10 | 135 | 0.21 |
| Oztekin, 2014 | P | No | 3 | 868 | 47 (16–82) | 1 | 690 | 12 | NA | 868 | 0.07 |
| Spick, 2015 | P | No | 1 | 111 | 51 (20–83) | 1 | NA | > 12 | 13.4 (6–44)ml 23.8 (6–75)nml | 111 | 0.14 |
| Strobel, 2015 | P | No | 3 | 340* | 53 (23–81) | 1 | 218 | > 18 | NA | 275 | 0.15 |
| Total | 2,316 | 0.14 |
P: patient selection; R: reference standard; H: histology; b: benign; m: malignant; FU: follow-up; NA: not available;
(*) patient subset fulfilling the selection criteria;
(**) 1 = BI-RADS 0, 2 = BI-RADS 3, 3 = other;
(***) 1 = histology and/or follow-up, 2 = histology only; m: malignant, b: benign, ml; mass lesions, nml: non-mass lesions