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. 2016 Mar 18;107(5):569–575. doi: 10.1111/cas.12913

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of high‐molecular‐weight hyaluronan (HMW‐HA) and low‐molecular‐weight (LMW)‐HA on the migration of pancreatic ductal adenocarcinoma cells assessed by Transwell assay. Left, photograph of migrated cells on the lower surface of the membrane under microscope. Right, average number of migrated cells counted in six randomly selected fields. Addition of exogenous HMW‐HA and, more robustly, LMW‐HA increases the migration of pancreatic ductal adenocarcinoma cells. *P < 0.05, **P < 0.01, ***P < 0.001, paired t‐test.