Figure 1.

Functional interactions among Gpr124, Reck, and Wnt7a/b‐triggered canonical Wnt signaling which promotes central nervous system (CNS) angiogenesis and blood–brain barrier (BBB) formation. New genetic studies in mouse and zebrafish indicate functions of Gpr124 and Reck to enhance canonical Wnt signaling induced by Wnt7a/b. Question marks denote possible molecular interactions. C, COOH‐terminus; CT, C‐terminal domain; GAIN, G protein‐coupled receptor autoproteolysis‐inducing; HRM, hormone receptor motif; IG, immunoglobulin domain; LRR, leucine‐rich repeat; N, NH₂‐terminus; PDZB, PDZ domain‐binding motif.3, 5, 14