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. 2016 Mar 28;107(5):609–618. doi: 10.1111/cas.12908

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Immunohistochemistry for CD44 variant 9 (CD44v9) in hepatitis C virus‐positive human (A) and mouse (B) hepatocellular carcinomas (HCCs). (A) CD44v9⁻ non‐recurrent HCC (a,b), normal‐appearing liver (c,d), and well (e,f), moderately (g,h), and poorly (i,j and k,l) differentiated CD44v9⁺ recurrent HCCs. Staining in human HCC used H&E (a,c,e,g,i,k) and CD44v9 (b,d,f,h,j,l). Note CD44v9⁺ cells (arrows) and positive multinuclear cells (l) in HCCs. (B) In mouse HCCs, note CD44v⁺ cells (a,b) and positive proliferative ductular epithelial cells in the mixed type tumor (c,d) (arrows). CD44v⁻ basophilic foci (e,f) and hepatocellular adenoma (HCA) (g,h) in mouse liver (serial sections).