Table 2.
Univariate and multivariate analyses of survival in hepatitis C virus‐positive patients with resected hepatocellular carcinoma (n = 90)
| Clinicopathological features | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| CD44v9 | ||||||
| Positive versus negative | 2.781 | 1.155–6.694 | 0.022 | 2.536 | 0.964–6.672 | 0.049 |
| Age, years | ||||||
| ≤70 versus >70 | 1.650 | 0.688–3.955 | 0.2620 | NA | ||
| Tumor size, cm3 | ||||||
| >2 versus ≤2 | 2.433 | 1.244–4.756 | 0.0090 | NA | ||
| T category | ||||||
| T2–4 versus T1 | 2.831 | 1.102–7.270 | 0.0310 | NA | ||
| Intrahepatic metastasis | ||||||
| Positive versus negative | 2.237 | 1.082‐4.627 | 0.0300 | NA | ||
| Venous invasion | ||||||
| Positive versus negative | 1.909 | 0.630–5.789 | <0.0001 | 2.450 | 1.116–5.379 | 0.026 |
| Infiltration to capsule | ||||||
| Positive versus negative | 2.055 | 1.011–4.176 | 0.0470 | 2.399 | 1.010–5.698 | 0.047 |
| Differentiation | ||||||
| Poor versus well/moderate | 2.125 | 1.046–4.314 | 0.0370 | NA | ||
| Stage | ||||||
| II–IV versus I | 2.831 | 1.102–7.270 | 0.0310 | NA | ||
| Recurrence | ||||||
| Positive versus negative | 2.770 | 1.216–6.310 | 0.0150 | 3.383 | 1.357–8.434 | 0.009 |
| Cirrhosis | ||||||
| Stage 3/4 versus stage 1/2 | 1.286 | 0.516–3.206 | 0.3790 | NA | ||
| AST, IU/L | ||||||
| >34 versus 13–33 | 0.988 | 0.478–2.041 | 0.9740 | NA | ||
| ALT, IU/L | ||||||
| >28 versus 6–27 | 0.965 | 0.491–1.896 | 0.9170 | NA | ||
| ALP, IU/L | ||||||
| >360 versus 115–359 IU/L | 0.850 | 0.420–1.721 | 0.6520 | NA | ||
Both multivariate and univariate analyses used Cox proportional‐hazards regression. Variables were adopted in multivariate analysis for their prognostic significance by univariate analysis. ALP, alkaline phosphatase; ALT, alanine transferase; AST, aspartate transferase; CD44v9, CD44 variant 9; NA, not available. No lymph node metastases were detected in any patient.