Figure 5.

Antitumor activity of DS‐5573a in MDA‐MB‐231‐bearing SCID mice. DS‐5573a at doses of 0.003–3 mg/kg or vehicle (PBS) was injected i.p. into MDA‐MB‐231‐bearing SCID mice once a week for 5 weeks (n = 10). The arrow shows the timing of DS‐5573a or vehicle injection. Data represent mean ± SEM. Estimated tumor volumes at 7 days after the final treatment were compared by Dunnett's test between the vehicle‐treated group and DS‐5573a‐treated groups. *P < 0.05, ***P < 0.001.