Fig. 1.

Rare variant rs188303909 near EN1 and associations with female total hip BMD Z-scores by age and Tanner stage. The T allele of rs188303909 associated with higher total hip aBMD Z-score; this association was stronger among the older and more mature females. The beta coefficients and standard errors are extracted from linear mixed-effects models with age × rs188303909 or Tanner stage × rs188303909 interaction terms. All models were adjusted for sex, BMI Z-score, physical activity, and dietary calcium.