Table 1.
Mutated antigens recognized by 3713 TIL
| Gene | Transcript ID | Chromosome: position |
Amino acid change |
cDNA change | Mutated amino acid sequence |
Wild type amino acid sequence |
HLA restriction element |
Mutant ic50 (nM) |
Mutant rank |
Wild type ic50 (nM) |
Wild type rank |
RPKM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SRPX | uc004ddy.2 | chrX:38033598 | P55L | C164T | TLWCSPIKV | TPWCSPIKV | A*02:01 | 12 | 0.6 | 12683 | 18 | 133 |
| WDR46 | uc003ods.3 | chr6:33254984 | T300I | C899T | FLIYLDVSV | FLTYLDVSV | A*02:01 | 5 | 0.3 | 8 | 0.4 | 40 |
| PRDX3 | uc001lec.3 | chr10:120933972 | P101L | C302T | FFYLLDFTF | FFYPLDFTF | A*29:02 | 16 | 0.4 | 7 | 0.3 | 49 |
| HELZ2 | uc002yfm.2 | chr20:62198871 | D614N | G1840A | QTNPVTLQY | QTDPVTLQY | A*29:02 | 18 | 0.4 | 144 | 1.2 | 20 |
| GCN1L1 | uc001txo.3 | chr12:120599720 | P769L | C2306T | IMQTLAGELY | IMQTPAGELY | A*29:02 | 43 | 0.4 | 49 | 0.4 | 18 |
| AFMID | uc002juz.3 | chr17:76198784 | A52V | C155T | EVLPFFLFF | EALPFFLFF | A*29:02 | 156 | 1.2 | 1003 | 2.8 | 11 |
| PLSCR4 | uc010huz.3 | chr3:145914466 | R247C | C739T | RVCGPCSTY | RVRGPCSTY | A*29:02 | 247 | 1.6 | 586 | 2.2 | 9 |
| CENPL | uc001gje.4 | chr1:173776589 | P79L | C236T | TLYSLTLLY | TLYSLTPLY | A*29:02 | 2 | 0.1 | 3 | 0.2 | 4 |
| TPX2 | uc010gdv.1 | chr20:30371683 | H458Y | C1480T | TEDEHFEFY | TEDEHFEFH | B*44:03 | 153 | 0.5 | 9325 | 4.4 | 55 |
| SEC22C | uc003clj.3 | chr3:42597481 | H218Y | C652T | AEHSLQVAY | AEHSLQVAH | B*44:03 | 13 | 0.2 | 589 | 1.1 | 23 |