Table 4.
Multinomial Logistic Regression Models for Treatment Preference
| Model 1-Demographic and clinical variables (n=1136) | Model 2 - All Variables (n=1090)# | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AS vs AT (ref) | No Preference vs AT (ref) | Overall p value | AS vs AT (ref) | No Preference vs AT (ref) | Overall p value | |||||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |||
| Age | ||||||||||
| less than 60 (ref) | 1 | 1 | 1 | 1 | ||||||
| 60-69 | 1.49 | 1.02 - 2.19 | 1.17 | 0.82 - 1.68 | 1.64 | 1.07 - 2.51 | 1.34 | 0.84 - 2.14 | ||
| 70+ | 1.79 | 0.94 - 3.39 | 1.05 | 0.55 - 2 | 2 | 0.95 - 4.18 | 1.02 | 0.43 - 2.42 | ||
| Education | * | |||||||||
| < High School (ref) | 1 | 1 | 1 | 1 | ||||||
| 1-3 Years College | 1.13 | 0.7 - 1.84 | 1.26 | 0.78 - 2.03 | 1.37 | 0.8 - 2.34 | 1.63 | 0.85 - 3.15 | ||
| 4 Year College | 1.29 | 0.77 - 2.17 | 1.73 | 1.05 - 2.85 | 1.61 | 0.9 - 2.89 | 2.19 | 1.1 - 4.36 | ||
| > Grad School | 1.71 | 1.02 - 2.87 | 2.29 | 1.38 - 3.8 | 2.05 | 1.12 - 3.74 | 2.84 | 1.42 - 5.69 | ||
| Race | ||||||||||
| Black(ref) | 1 | 1 | 1 | 1 | ||||||
| White | 1.44 | 0.83 - 2.51 | 0.85 | 0.52 - 1.4 | 1.28 | 0.71 - 2.3 | 0.71 | 0.38 - 1.33 | ||
| Other | 2.1 | 0.92 - 4.79 | 0.99 | 0.45 - 2.18 | 1.59 | 0.64 - 3.94 | 0.68 | 0.24 - 1.91 | ||
| Elixhauser Index | ||||||||||
| 0 (ref) | 1 | 1 | 1 | 1 | ||||||
| 1 | 0.9 | 0.58 - 1.4 | 1.15 | 0.76 - 1.75 | 0.87 | 0.54 - 1.4 | 1.09 | 0.64 - 1.86 | ||
| 2 | 0.65 | 0.38 - 1.12 | 1.13 | 0.69 - 1.83 | 0.7 | 0.39 - 1.27 | 1.36 | 0.73 - 2.55 | ||
| 3+ | 1.14 | 0.71 - 1.82 | 0.84 | 0.53 - 1.35 | 1.19 | 0.7 - 2.01 | 0.72 | 0.38 - 1.35 | ||
| PSA at diagnosis | ||||||||||
| <= 4 (ref) | 1 | 1 | 1 | 1 | ||||||
| 4.1 to 7.9 | 1.32 | 0.74 - 2.37 | 0.87 | 0.52 - 1.45 | 1.14 | 0.6 - 2.15 | 0.88 | 0.44 - 1.76 | ||
| 8.0 to 10.0 | 0.79 | 0.39 - 1.61 | 0.73 | 0.38 - 1.38 | 0.56 | 0.26 - 1.23 | 0.75 | 0.32 - 1.72 | ||
| Days from Diagnosis to Baseline | ||||||||||
| (one-unit increase = 1 SD) | 1.18 | 0.99 - 1.4 | 1.03 | 0.87 - 1.23 | 1.19 | 0.98 - 1.44 | 0.97 | 0.77 - 1.21 | ||
| Number of positive cores | 0.73 | 0.66 - 0.81 | 0.96 | 0.9 - 1.03 | *** | 0.74 | 0.67 - 0.82 | 0.95 | 0.86 - 1.04 | *** |
| First Degree relative with prostate cancer | *** | ** | ||||||||
| No (ref) | 1 | 1 | 1 | 1 | ||||||
| Yes | 0.61 | 0.42 - 0.88 | 0.55 | 0.38 - 0.78 | 0.58 | 0.38 - 0.87 | 0.56 | 0.35 - 0.88 | ||
| Urologist Recommendation | *** | *** | ||||||||
| No recommendation/Patient Decide (ref) | ||||||||||
| AS/WW | 20.02 | 10.36 - 38.7 | 3.15 | 1.5 - 6.61 | 17.89 | 8.98 - 35.66 | 2.58 | 1.09 - 6.08 | ||
| AT | 0.43 | 0.29 - 0.66 | 0.64 | 0.45 - 0.93 | 0.41 | 0.26 - 0.65 | 0.56 | 0.34 - 0.92 | ||
| no discussion with urologist | 4.58 | 2.17 - 9.69 | 12.27 | 6.08 - 24.76 | 3.38 | 1.51 - 7.57 | 5.62 | 2.41 - 13.11 | ||
| # of decision making resources used | *** | |||||||||
| 0/1 (ref) | -- | -- | -- | -- | 1 | 1 | ||||
| 2 | -- | -- | -- | -- | 0.64 | 0.36 - 1.14 | 0.81 | 0.41 - 1.6 | ||
| 3 | -- | -- | -- | -- | 0.39 | 0.21 - 0.71 | 1.01 | 0.5 - 2 | ||
| 4+ | -- | -- | -- | -- | 0.28 | 0.15 - 0.52 | 0.81 | 0.4 - 1.66 | ||
| Sure Scale (certainty about treatment preference) | *** | |||||||||
| (one-unit increase = 1 SD) | -- | -- | -- | -- | 0.57 | 0.41 - 0.8 | 0.13 | 0.09 - 0.17 | ||
| Health Worry Scale (prostate cancer anxiety) | ||||||||||
| (one-unit increase = 1 SD) | -- | -- | -- | -- | 1.22 | 1.003 - 1.48 | 1.05 | 0.84 - 1.31 | ||
| Degner Control Preference Scale | *** | |||||||||
| Decision with Doctor or Independent (ref) | -- | -- | -- | -- | 1 | 1 | ||||
| Shared decision | -- | -- | -- | -- | 2.34 | 1.37 - 3.99 | 3.09 | 1.73 - 5.52 | ||
| Knowledge Scale | *** | |||||||||
| (one-unit increase = 1 SD) | -- | -- | -- | -- | 1.77 | 1.43 - 2.18 | 1.63 | 1.28 - 2.06 | ||
| Awareness of Low Risk Level | *** | |||||||||
| Incorrect/DK (ref) | -- | -- | -- | -- | 1 | 1 | ||||
| Correct (low risk) | 3.97 | 1.96 - 8.06 | 1.74 | 0.87 - 3.48 | ||||||
Notes: AS (active surveillance), AT (active treatment), NP (no preference).
#
Model 2 has fewer subjects than Model 1 due to missing data in the psychological and decisional variables included in Model 2.
*
p value <0.05
**
p value <0.01
***
p value <0.001