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Relationship between lipophilicity and potency of fluoroquinolones. Potency of a series of fluoroquinolones was measured as the MIC against Staphylococcus aureus (A) and E. coli (B); MIC data are from Takenouchi et al. (1996) and Clog P was obtained from PubChem Compound. As lipophilicity (and hydrophobicity) increase, so potency increases also.
