Figure 5.

The effect of tested compounds on the blood pressure response to methoxamine. Rats were anesthetized with intraperitoneal injection of thiopental (75 mg/kg). The studied compounds were administered intravenously (i.v.), at the lowest hypotensive doses i.e., 0.625 mg/kg (HBK-14), 5.0 mg/kg (HBK-15), 0.1 mg/kg (HBK-16), 0.1 mg/kg (HBK-17), 0.01 mg/kg (HBK-18), 0.625 mg/kg (HBK-19). Methoxamine (MET) was administered at the dose 150 μg/kg (i.v.). All values represent means ± S.E.M. Statistical analysis: Student's t-test; ^*p < 0.05, ^**p < 0.01, compared to the initial maximal response (obtained before the administration of tested compounds). n = 5−6 animals per group.