Table 4.
The antiarrhythmic activity of 2-methoxy phenylpiperazine derivatives in prophylactic model of adrenaline induced arrhythmia.
| Compound | Dose (mg/kg) | Extrasystoles (%) | Bigeminy (%) | Bradycardia (%) | Blocks (%) |
|---|---|---|---|---|---|
| Adrenaline | – | 66.7 | 33.3 | 66.7 | 50.0 |
| HBK-14 | 2.5 | 100.0 | 50.0 | 83.3 | 83.3 |
| 5 | 50.0 | 33.3 | 50.0 | 33.3 | |
| 10 | 16.7 | 16.7 | 50.0 | 33.3 | |
| HBK-15 | 2.5 | 66.7 | 33.3 | 66.7 | 66.7 |
| 5 | 50.0 | 16.7 | 66.7 | 50.0 | |
| 10 | 33.3 | 16.7 | 50.0 | 33.3 | |
| HBK-16 | 0.1 | 83.3 | 33.3 | 66.7 | 50.0 |
| 0.2 | 33.3 | 16.7 | 50.0 | 33.3 | |
| 0.3 | 16.7 | – | 33.3 | 16.7 | |
| HBK-17 | 0.1 | 66.7 | 50.0 | 67.7 | 67.7 |
| 0.2 | 50.0 | 33.3 | 50.0 | 33.3 | |
| 0.3 | 16.7 | 16.7 | 33.3 | 16.7 | |
| HBK-18 | 0.1 | 83.3 | 50.0 | 66.7 | 66.7 |
| 0.2 | 50.0 | 16.7 | 50.0 | 33.0 | |
| 0.3 | 16.7 | 12.0 | 16.3 | 16.3 | |
| HBK-19 | 0.1 | 66.7 | 33.3 | 66.7 | 50.0 |
| 0.2 | 50.0 | 16.7 | 33.3 | 33.3 | |
| 0.3 | 16.7 | – | 16.7 | 16.7 |
Rats were anesthetized with intraperitoneal (i.p.) injection of thiopental (75 mg/kg). The tested compounds were administered (i.p.) 45 min before the experiment. The observation was carried out for 15 min after the intravenous injection of adrenaline (20 μg/kg) i.e., during the first 2 min, in the 5, 10, and 15th min. n = 5−6 animals per group.