Table 1.
Numbers of age-related genes in 13 GTEx brain regions.
| FDR | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1% | 5% | 10% | |||||||
| Brain Region | Up | Down | Total | Up | Down | Total | Up | Down | Total |
| (1) Amygdala (n = 67) | 0 | 0 | 0 | 0 | 1 | 1 | 8 | 9 | 17 |
| (2) Anterior Cingulate Cortex (BA24) (n = 77) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| (3) Caudate (basal ganglia) (n = 101) | 23 | 26 | 49 | 171 | 176 | 347 | 355 | 390 | 745 |
| (4) Cerebellar Hemisphere (Frozen) (n = 93) | 0 | 0 | 0 | 2 | 8 | 10 | 23 | 35 | 58 |
| (5) Cerebellum (PAXgene) (n = 110) | 54 | 86 | 140 | 358 | 466 | 824 | 688 | 788 | 1476 |
| (6) Cortex (PAXgene) (n = 97) | 2 | 4 | 6 | 52 | 64 | 116 | 139 | 184 | 323 |
| (7) Frontal Cortex (BA9) (Frozen) (n = 95) | 0 | 0 | 0 | 2 | 2 | 4 | 2 | 3 | 5 |
| (8) Hippocampus (n = 82) | 0 | 0 | 0 | 5 | 2 | 7 | 87 | 42 | 129 |
| (9) Hypothalamus (n = 86) | 0 | 0 | 0 | 20 | 22 | 42 | 84 | 81 | 165 |
| (10) Nucleus Accumbens (basal ganglia) (n = 97) | 6 | 5 | 11 | 34 | 33 | 67 | 104 | 91 | 195 |
| (11) Putamen (basal ganglia) (n = 85) | 11 | 9 | 20 | 110 | 105 | 215 | 257 | 268 | 525 |
| (12) Spinal Cord (cervical c-1) (n = 64) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| (13) Substantia Nigra (n = 54) | 0 | 0 | 0 | 1 | 2 | 3 | 1 | 2 | 3 |
Columns “Up” and “Down” list the numbers of up-regulated and down-regulated aging genes, respectively. Results derived from using three different FDR cutoffs (1, 5, and 10%) are shown. Two regions, (5) Cerebellum (PAXgene) and (6) Cortex (PAXgene), for which samples were preserved using the PAXgene tissue preservation system, are highlighted in bold.