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. 2016 Aug 3;10:55. doi: 10.3389/fncir.2016.00055

Figure 5.

Figure 5

Expression of cortical layer-specific transcription factors within the graft from D2 to D30 (A–R). (A–J) Immunohistochemistry for GFP (green) and the transcription factors Ctip2 (red) and Cux1 (blue) within the graft and host cortex from D2 to D30. (G,H) The superficial and deep cortical layers of the host cortex are labeled by Cux1 (blue, layers II-IV) and Ctip2 (red, layers V-VI). (G–J). The grafts were organized in clusters in which Ctip2 and Cux1 expression tend to be mutually exclusive. (K–T) Immunohistochemistry for GFP (green) and the transcription factors Foxp2 (red) and Tbr1 (blue) within the graft and host cortex from D2 to D30. (K–T) Tbr1+ and Foxp2+ cells were uniformly distributed through the grafts and the majority of the labeled cells co-expressed both markers corresponding to deep layer neurons (Tbr1, Foxp2). T, transplant; H, Host. Dashed lines indicate transplant-host border. Scale bar: 150 μm.