Table 1.

Study Subject Characteristics

ID	Initial Clinical Diagnosis						Evidence for Reversal					Evidence for Relapse				Kisspeptin Study
	Age at Dx	Smell Defect UPSIT	TV	LH	FSH	T	Age at Reversal	TV	LH	FSH	T	TV	LH	FSH	T	Age at Study	TV	LH	FSH	T	Kiss-10 Response	Category
1	19 y	Mild hyposmia	12/12			16	21	15/15			265					26	15/20	2.3	3.6	276	+	Reversal
2	17 y 11 mo	Mild hyposmia	12/12	0.6	1.1	53	21	15/15								21	25/25	5	2.6	555	+	Reversal
3	18 y 8 mo	Normal	12/12	1.15	0.32	28	19 y 9 mo	20/20			520					21	25/25			379	+	Reversal
4	18 y 2 mo	Mild hyposmia	Inguinal/4	2.3	2.3	63	19	10/12								24	10/15	2.3	3	374	+	Reversal
5	27 y	Reports no smell	4/4			16	31	12/12								32	12/12	0.49	0.3	18	−	Relapsed
6	17–18 y	Normal	3/3	Low	Low	Low	34	15/20				15/20	0.8	0.9	<20	36	25/20	On exogenous T			−	Relapsed

Dx, diagnosis; TV, testicular volume in cc; LH, luteinizing hormone in mIU/mL; FSH, follicle stimulating hormone in mIU/mL; T, testosterone in ng/dL; UPSIT, University of Pennsylvania Smell Identification Test.