Figure 1.

Disease histories of Norwegian APS1 patients. The lines start at birth and end at death (bracket) or at current age (>). Age at appearance of disease component is indicated by a symbol of the disease. Disease components of uncertain time of onset are listed at the end of the line. The major disease components CMC, HP, and PAI are marked in red, blue, and green, respectively. Al, alopecia; AS, asplenia; AT, hypothyroidism; Ca, cancer; DM, diabetes mellitus; E, enamel hypoplasia/defects; G, hypogonadism; H, hepatitis; HP, hypoparathyroidism; K, keratoconjunctivitis; M, malabsorption; N, nail dystrophy; P, pancreas failure exocrine; PA, pernicious anemia; PS, psoriasis; TIN, tubule interstinal nephritis; V, vitiligo.