Table 1.
Survival data of 145 animals
| Animals (n) | MCAo length (min) | TAT.application: Time/dose | TAT.β-Gal–sham: n/death event (day) | TAT.β-Gal–MCAo: n/death event (day) | TAT.ARC–sham: n/death event (day) | TAT.ARC–MCAo: n/death event (day) | Number of animals at survival endpoint | Data shown |
|---|---|---|---|---|---|---|---|---|
| 24 | 60 | During MCAo [1 μg] | — | 12/1 (1); | — | 12/0 (n/a) | 23/3 d | Figs. 2, 3, 5, 6 |
| 30 | 60 | 3 h post MCAo [5 μg] | — | 15/0 (n/a) | — | 15/1a (1) | 29/3 d | Fig. 7 |
| 40 | 60 | During MCAo [1 μg] | 5/0 (n/a) | 15/0 (n/a) | 5/0 (n/a) | 15/0 (n/a) | 40/3–24 h | Figs. 4, 6 |
| 5 | n/a | TAT.ARCL31F/G69R | — | — | 5/0 (n/a) | — | 5/24 h | Fig. 6 |
| 46 | 30 | 3 h post MCAo [5 μg] | 8/0 (n/a) | 15/1 (7) | 8/0 (n/a) | 15/4 (1, 7, 8, 10) | 41/28 db | Fig. 8 |
aSurvival was tested with the log-rank Mantel–Cox test with χ2 = 6.081 (df = 3) and p = 0.11 indicative that survival did not differ between groups in the last experiment.
bAnimal died after MCAo before TAT.application.