A, Cocaine self-administration in LgA rats, but not ShA rats increased over time. #Significant increase vs session 14 (t test, p < 0.05). B, C, The initial drug loading (B) and the motivation to work for cocaine (C) were increased in LgA rats compared with ShA rats. ∧Significant difference (one-way ANOVA, p < 0.05) compared with ShA (B, C). *Significant difference (one-way ANOVA, p < 0.05) compared with session 14 (B); n.s., No change compared with session 14 (B). ShA, n = 11; LgA, n = 11.