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A, Re-escalation of cocaine intake in rats with a history of LgA, but not in rats with a history of ShA, to cocaine. #Significant increase vs session 70 (t test, p < 0.05). B, Slower extinction of responding in rats with a history of LgA cocaine self-administration. #Significant increase (t test, p < 0.05) vs average of sessions 89–91 (= 10 infusions in 4 h = less than 3 infusions per h). ShA, n = 9; LgA, n = 10.
