Table 1.
Effects of TC on absolute number of active and inactive lever presses
| Group | Experiment name | Number of active lever presses | Number of active lever presses during timeout | Number of inactive lever presses |
|---|---|---|---|---|
| A | FR ShA self-administration (0–60 min) | TE: 15.5 ± 2.5 vs TC: 5.3 ± 1.9 | TE: 2.6 ± 0.6 vs TC: 1.5 ± 0.7 | TE: 2.1 ± 0.7 vs TC: 1.3 ± 0.7 |
| F(1,20) = 10.63, p = 0.004 | n.s. | n.s. | ||
| FR LgA self-administration (0–30 min) | TE: 16.0 ± 0.9 vs TC: 8.9 ± 1.6 | TE: 2.2 ± 0.5 vs TC: 1.1 ± 0.5 | TE: 1.4 ± 0.4 vs TC: 1.5 ± 0.6 | |
| F(1,20) = 15.56, p < 0.001 | n.s. | n.s. | ||
| FR LgA self-administration (30–60 min) | TE: 12.5 ± 0.4 vs TC: 7.5 ± 1.5 | TE: 1.2 ± 0.6 vs TC: 0.7 ± 0.3 | TE: 0.1 ± 0.1 vs TC: 0.0 ± 0.0 | |
| F(1,20) = 10.16, p = 0.005 | n.s. | n.s. | ||
| FR LgA self-administration (60–90 min) | TE: 12.3 ± 0.5 vs TC: 8.6 ± 1.6 | TE: 1.5 ± 0.6 vs TC: 0.8 ± 0.7 | TE: 0.0 ± 0.0 vs TC: 0.4 ± 0.4 | |
| F(1,20) = 5.17, p = 0.034 | n.s. | n.s. | ||
| FR LgA self-administration (90–120 min) | TE: 12.0 ± 0.4 vs TC: 10.0 ± 1.3 | TE: 1.0 ± 0.3 vs TC: 0.9 ± 0.5 | TE: 0.1 ± 0.1 vs TC: 0.3 ± 0.3 | |
| n.s. | n.s. | n.s. | ||
| PR self-administration after ShA | TE: 136.7 ± 49.2 vs TC: 25.0 ± 12.4 | TE: 2.7 ± 0.8 vs TC: 2.1 ± 1.0 | TE: 3.3 ± 1.1 vs TC: 3.1 ± 1.1 | |
| F(1,18) = 4.84, p = 0.041 | n.s. | n.s. | ||
| PR self-administration after LgA | TE: 279.4 ± 37.5 vs TC: 150.7 ± 44.6 | TE: 3.1 ± 0.6 vs TC: 1.9 ± 0.9 | TE: 2.9 ± 1.0 vs TC: 3.2 ± 1.0 | |
| F(1,20) = 4.88, p = 0.039 | n.s. | n.s. | ||
| B | Glucose/saccharin self-administration after ShA | TE: 35.9 ± 4.6 vs TC: 35.0 ± 4.6 | TE: 3.4 ± 0.8 vs TC: 2.5 ± 1.1 | TE: 2.7 ± 0.5 vs TC: 1.9 ± 0.5 |
| n.s. | n.s. | n.s. | ||
| Glucose/saccharin self-administration after LgA | TE: 35.9 ± 3.1 vs TC: 35.9 ± 3.4 | TE: 3.5 ± 0.9 vs TC: 2.4 ± 0.9 | TE: 2.2 ± 0.5 vs TC: 2.5 ± 0.7 | |
| n.s. | n.s. | n.s. | ||
| C | Reinstatement of self-administration after ShA | TE: 10.6 ± 2.1 vs TC: 5.2 ± 0.9 | TE: 1.1 ± 0.4 vs TC: 0.2 ± 0.1 | TE: 2.3 ± 0.5 vs TC: 1.4 ± 1.3 |
| F(1,16) = 5.23, p = 0.036 | F(1,16) = 3.94, p = 0.065 | n.s. | ||
| Reinstatement of self-administration after LgA | TE: 14.5 ± 2.1 vs TC: 8.0 ± 1.4 | TE: 4.6 ± 0.7 vs TC: 2.0 ± 0.7 | TE: 2.2 ± 0.5 vs TC: 1.5 ± 1.2 | |
| F(1,18) = 6.42, p = 0.021 | F(1,18) = 6.18, p = 0.023 | n.s. |
Effects of 7.5 mg/kg TC on the number of active and inactive lever presses, as well as active lever pressing during the timeout period. TC reduced the number of active lever presses to obtain cocaine without affecting either inactive lever pressing or the number of active lever presses to obtain a glucose/saccharin solution. Values shown are mean number of lever presses ± SEM following either TE or TC pretreatment. F and p values were obtained using a one-way ANOVA with the factor treatment.