FIG. 2.

(A) Shows the breakdown of CD8⁺ T cells in whole blood and CSF that had a central memory, effector memory, or “TEMRA” (terminally differentiated, RA expressing) phenotype. HC, HIV controllers (blue shapes); NC, noncontrollers (red shapes); Tx, subjects on ART with VL <50 (green shapes); Neg, HIV-negative controls (black shapes). Lines and asterisks above the graphs indicate p values for statistically significant differences between groups (*p < .05; **p < .01). (B) Summarizes the percentages of HIV-specific CD8⁺ T cells (i.e., binding MHC class I multimers) that were effector memory cells. ART, antiretroviral therapy; VL, viral load.