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. 2016 Aug 3;6:31169. doi: 10.1038/srep31169

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Copyright © 2016, The Author(s)

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(A) Immunohis-tochemical staining of ROS. Increased ROS activity was inhibited by cilostazol treatment. Scale bar = 200 μm. (B) Images of the in situ zymographic analysis of gelatinase and MMP-9 and (C) the related histogram analysis. Skin treated with cilostazol showed significant suppression of gelatinase activity and MMP-9 expression. ^*P < 0.05 vs. non-treated skin with cilostazol. Scale bar = 200 μm. (D) Immunohistochemical images of NF-κB and (E) the related histogram analysis. The significant increase in phosphorylated p38 MAPK and NF-κB by UVB irradiation was attenuated by cilostazol treatment. ^***P < 0.001 vs. non-treated skin with cilostazol. Scale bar = 100 μm.