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. 2016 Aug 3;6:31085. doi: 10.1038/srep31085

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The high expression of p18 in somatic cells inhibits Cdk4/6 activity, leading to compromised G1/S and G2/M transition. Somatic cell reprogramming is therefore blocked.