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. 2016 Aug 3;6:30899. doi: 10.1038/srep30899

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Copyright © 2016, The Author(s)

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(A) Probabilities of LTP (P_LTP), LTD (P_LTD), and failure (P_Failure) of inductions of synaptic plasticity for the control model stimulated with Ca²⁺ pulses of 20 s of duration and different peak concentrations. (B–J) P_LTP, P_LTP, and P_Failure obtained for Ca²⁺ pulses of 20 s for modified versions of the model with an increase of [CaN] (B), decrease of [CaN] (C), absence of CaN (D), increase of [PP1] (E), decrease of [PP1] (F), increase of [PP2A] (G), decrease of [PP2A] (H), increase of [αCaMKII] (I), and decrease of [αCaMKII] (J). For each Ca²⁺ concentration in each panel, we analysed the results of 50–100 single runs of the model.